abstract：:Patients with paroxysmal nocturnal hemoglobinuria (PNH) may present with thrombosis at unusual sites, of which cerebral sinovenous thrombosis (CSVT) is one and screening for PNH is recommended in this condition. Though many patients diagnosed with PNH develop CSVT, it is unclear how many patients with PNH would presen...

journal_title：Journal of thrombosis and thrombolysis

authors： Sharma S,Ahluwalia J,Atreja CB,Modi M,Sachdeva MS,Kumar N,Bose P,Bose SK,Uppal V,Lal V,Varma N

更新日期：2020-05-01 00:00:00

abstract：:Postmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS pa...

journal_title：Journal of thrombosis and thrombolysis

authors： Kim HO,Kim CJ,Kim W,Cho JM,Soeda T,Takano M,Yan BP,Crea F,Niccoli G,Vergallo R,Minami Y,Higuma T,Kimura S,Boeder NF,Nef H,Adriaenssens T,Kurihara O,Thondapu V,Russo M,Yamamoto E,Sugiyama T,Lee H,Kakuta T,Yon

更新日期：2020-04-01 00:00:00

abstract：:Peripherally inserted central catheters (PICCs) for central venous access are frequently used in patients with hematological malignancies. Their use may be complicated by upper extremity deep venous thrombosis (UEDVT). Additionally, hematological patients are frequently thrombocytopenic and the optimal management of U...

journal_title：Journal of thrombosis and thrombolysis

authors： Scamuffa MC,Morano SG,Serrao A,Bruzzese A,Stocchi F,Santoro C,Vozella F,Latagliata R,Chistolini A

更新日期：2020-04-01 00:00:00

abstract：:The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by emulsion solvent evaporation method and optimized using central composite design (CDD). The optimized RXB-PLGA-NPs (F8) with composition, PLGA ...

journal_title：Journal of thrombosis and thrombolysis

authors： Anwer MK,Mohammad M,Iqbal M,Ansari MN,Ezzeldin E,Fatima F,Alshahrani SM,Aldawsari MF,Alalaiwe A,Alzahrani AA,Aldayel AM

更新日期：2020-04-01 00:00:00

abstract：:The direct oral anticoagulant dabigatran does not require therapeutic drug monitoring, however emergency measurements are gaining importance. Current assays feature good performance at intermediate and high dabigatran concentrations but show limited accuracy at low concentrations. This area requires more attention as ...

journal_title：Journal of thrombosis and thrombolysis

authors： Härtig F,Poli S,Ebner M,Birschmann I,Kuhn J,Ziemann U,Häring HU,Lehmann R,Peter A,Hörber S

更新日期：2020-04-01 00:00:00

abstract：:Thrombosis resolution is an important component of treatment for deep vein thrombosis (DVT) and multiple anticoagulants are now available. It is unknown whether rivaroxaban contributes to a higher degree of thrombus resolution compared to conventional anticoagulation with warfarin. Our objective was to compare thrombu...

journal_title：Journal of thrombosis and thrombolysis

authors： Houghton DE,Lekah A,Macedo TA,Hodge D,Saadiq RA,Little Y,Casanegra AI,McBane RD,Wysokinski WE

更新日期：2020-02-01 00:00:00

abstract：:Pylephlebitis, or suppurative thrombophlebitis of the portal vein, typically occurs in the context of an intraabdominal infection or abdominal sepsis. Antibiotics are the mainstay of treatment. The role of anticoagulation in the management of pylephlebitis is controversial, and data regarding its impact on outcomes is...

journal_title：Journal of thrombosis and thrombolysis

authors： Naymagon L,Tremblay D,Schiano T,Mascarenhas J

更新日期：2020-02-01 00:00:00

abstract：:The best strategy in atrial fibrillation (AF) after > 12 months after an acute coronary syndrome or in patients with chronic coronary syndrome without an indication for interventional revascularization remains unclear. European guidelines generally recommend therapy with oral anticoagulation (OAC) alone, whereas North...

journal_title：Journal of thrombosis and thrombolysis

authors： Wernly B,Bhatt DL,Polzin A,Jung C

更新日期：2020-02-01 00:00:00

abstract：:Fibrinolysis is regulated by the thrombin/thrombin-activatable fibrinolysis inhibitor (TAFI) system. Thus, anticoagulants and inhibitors of TAFI are expected to accelerate fibrinolysis. The combined effects of an anticoagulant and a TAFIa inhibitor on fibrinolysis remain unknown. The aim of this study was to evaluate ...

journal_title：Journal of thrombosis and thrombolysis

authors： Morishima Y,Kamisato C,Honda Y

更新日期：2020-01-01 00:00:00

abstract：:Half of patients with atrial fibrillation (AF) and elevated stroke risk do not receive anticoagulation (AC). Explanations for undertreatment may relate to provider lack of confidence with or knowledge of the CHA2DS2-VASc stroke calculator, unfamiliarity with direct oral anticoagulants (DOACs), or uncertainty about use...

journal_title：Journal of thrombosis and thrombolysis

authors： Amroze A,Mazor K,Crawford S,O'Day K,McManus DD,Kapoor A

更新日期：2019-11-01 00:00:00

abstract：:Venous ulcers are the most severe manifestation of post-thrombotic syndrome (PTS). We have previously demonstrated that formation of compact fibrin clots resistant to lysis is observed in patients following deep-vein thrombosis (DVT) who developed PTS. The current study investigated whether unfavourable fibrin clot pr...

journal_title：Journal of thrombosis and thrombolysis

authors： Polak MW,Siudut J,Plens K,Undas A

更新日期：2019-11-01 00:00:00

abstract：:We included acute ischemic stroke (AIS) patients who received recombinant tissue plasminogen activator (rt-PA) at three stroke centers via either interhospital transfer or direct presentation and compared the clinical outcomes and time metrics to analyze the impact of interhospital transfer on intravenous thrombolysis...

journal_title：Journal of thrombosis and thrombolysis

authors： Ding Y,Ji Z,Ma L,Zhai T,Gu Z,Niu J,Liu Y

更新日期：2019-11-01 00:00:00

abstract：:Venous thromboembolism (VTE) is an important cause of morbidity and mortality in Western countries. The incidence rate of VTE is estimated at 1-2 cases per 1000 annually. This study was a population-based cohort study of previously treatment naïve patients with a first occurrence of venous thromboembolism (VTE), using...

journal_title：Journal of thrombosis and thrombolysis

authors： Wändell P,Forslund T,Danin Mankowitz H,Ugarph-Morawski A,Eliasson S,Braunschwieg F,Holmström M

更新日期：2019-11-01 00:00:00

abstract：:Certain patient populations (pregnancy, cancer, renal impairment, and obesity) may be at higher risk of adverse events during low molecular weight heparin (LMWH) therapy and may benefit from anti-Xa monitoring. Yet, evidence supporting a standardized approach to anti-Xa monitoring correlated to clinical outcomes is la...

journal_title：Journal of thrombosis and thrombolysis

authors： Lin A,Vazquez SR,Jones AE,Witt DM

更新日期：2019-11-01 00:00:00

abstract：:The concept of a pulmonary embolism response team (PERT) is multidisciplinary, with the hope that it may positively impact patient care, hospital efficiency, and outcomes in the treatment of patients with intermediate and high risk pulmonary embolism (PE). Clinical characteristics of a baseline population of patients ...

journal_title：Journal of thrombosis and thrombolysis

authors： Wright C,Elbadawi A,Chen YL,Patel D,Mazzillo J,Acquisto N,Groth C,Van Galen J,Delehanty J,Pietropaoli A,Trawick D,James White R,Cameron P,Gosev I,Barrus B,Kumar NG,Cameron SJ

更新日期：2019-08-01 00:00:00

abstract：:Data on LA/LAA thrombus resolution after rivaroxaban treatment has not been established. The aim of the present study was to compare the efficacy and safety on the resolution of LA/LAA thrombus between rivaroxaban and warfarin in nonvalvular atrial fibrillation (AF) patients. 80 AF patients with LA/LAA thrombus betwee...

journal_title：Journal of thrombosis and thrombolysis

authors： Ke HH,He Y,Lv XW,Zhang EH,Wei Z,Li JY

更新日期：2019-08-01 00:00:00

abstract：:Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the effect of chemotherapy on pro-coagul...

journal_title：Journal of thrombosis and thrombolysis

authors： Pluchart C,Poitevin G,Colinart-Thomas M,Guimard G,Audonnet S,Terryn C,Nguyen P

更新日期：2019-08-01 00:00:00

abstract：:Coronary artery fistulae (CAF) are rare congenital or acquired in which a connection forms between one of the coronary arteries and a heart chamber or with other vessels. This paper describes three cases of CAF along with their initial presentation, imaging findings and management. The first case is a rare form of CAF...

journal_title：Journal of thrombosis and thrombolysis

authors： Ali M,Kassem KM,Osei K,Effat M

更新日期：2019-08-01 00:00:00

abstract：:Patients with carotid atherosclerosis, especially the elderly population, take antithrombotic medicine regularly. However, no previous meta-analysis has focused on one of the possible side effects of such drugs, namely intraplaque hemorrhage (IPH). To determine whether antiplatelet drugs or anticoagulants are associat...

journal_title：Journal of thrombosis and thrombolysis

authors： Cao X,Zhang J,Geng D

更新日期：2019-07-01 00:00:00

abstract：:Anti-platelet agents or anticoagulants are administered for patients with multiple myeloma (MM) receiving immunomodulatory drugs (IMiDs) to prevent thrombotic events (TEs). However, there is a discrepancy between current guidelines and clinical practice in thromboprophylaxis and the varied incidence of TEs depending o...

journal_title：Journal of thrombosis and thrombolysis

authors： Takaishi K,Tsukamoto S,Ohwada C,Takeuchi M,Kawasaki Y,Nagai Y,Mishina T,Yamazaki M,Isshiki Y,Kayamori K,Kimura K,Hino Y,Oshima-Hasegawa N,Mitsukawa S,Takeda Y,Mimura N,Iseki T,Nakaseko C,Sakaida E

更新日期：2019-07-01 00:00:00

abstract：:In patients with active cancer and acute venous thromboembolism (VTE), the low-molecular-weight-heparin (LMWH) dalteparin is more effective than vitamin K antagonist (VKA) in reducing the risk of recurrent venous thromboembolism (rVTE) without increasing the risk of bleeding. However, the relative benefit of LMWH vers...

journal_title：Journal of thrombosis and thrombolysis

authors： Woodruff S,Lee AYY,Carrier M,Feugère G,Abreu P,Heissler J

更新日期：2019-05-01 00:00:00

abstract：:Warfarin is dependent on multiple hepatic enzymes for metabolism while apixaban is a substrate for P-glycoprotein (P-gp) transport and hepatic CYP3A4 metabolism. The aim of this analysis was to assess the impact of interacting medication use on the treatment effects of apixaban versus warfarin. Outcomes were compared ...

journal_title：Journal of thrombosis and thrombolysis

authors： Washam JB,Hohnloser SH,Lopes RD,Wojdyla DM,Vinereanu D,Alexander JH,Gersh BJ,Hanna M,Horowitz J,Hylek EM,Xavier D,Verheugt FWA,Wallentin L,Granger CB,ARISTOTLE Committees and Investigators.

更新日期：2019-04-01 00:00:00

abstract：:Cancer is associated with an increased risk of venous thromboembolism of four to sixfold. Cancer-related interventions such as chemotherapy, hormonal therapy and indwelling central venous catheters also increase the risk of venous thromboembolism. Low molecular weight heparin for at least 3-6 months is the current sta...

journal_title：Journal of thrombosis and thrombolysis

authors： Franco-Moreno A,Cabezón-Gutiérrez L,Palka-Kotlowsa M,Villamayor-Delgado M,García-Navarro M

更新日期：2019-04-01 00:00:00

abstract：:Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese physicians and provide the basis for establishing Chinese clinical guidelines on PE. We designed a nationwide survey to collect data on physicians' awareness of diagno...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang M,Zhang YX,Zhang Z,Wang J,Shao X,Xie WM,Wan J,Zhai ZG,Wang C

更新日期：2019-04-01 00:00:00

abstract：:Recurrent stroke is common immediately following a transient ischemic attack (TIA) or ischemic stroke. Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin may provide greater protection against subsequent stroke than monotherapy. Electronic databases were searched for randomized clinical trials (RCTs) compar...

journal_title：Journal of thrombosis and thrombolysis

authors： Kheiri B,Osman M,Abdalla A,Haykal T,Swaid B,Ahmed S,Chahine A,Hassan M,Bachuwa G,Al Qasmi M,Bhatt DL

更新日期：2019-02-01 00:00:00

abstract：:Ischemic stroke and major bleeding, mostly due to intracranial hemorrhage (ICH), cause about the same rates of death in pivotal randomized trials of direct oral anticoagulants (DOACs) versus warfarin for stroke prevention in atrial fibrillation (AF). We analyzed our AF inpatient database to determine whether any ICH-r...

journal_title：Journal of thrombosis and thrombolysis

authors： Chopard R,Piazza G,Hurwitz S,Fanikos J,Goldhaber SZ

更新日期：2019-02-01 00:00:00

abstract：:Associations of Raynaud's phenomenon (RP) with venous thromboembolism (VTE) are unclear. We investigated the occurrence of RP together with prothrombotic state markers and fibrin clot properties in VTE patients. In this prospective cohort study we enrolled 360 patients free of known autoimmune disease. D-dimer, von Wi...

journal_title：Journal of thrombosis and thrombolysis

authors： Żuk J,Snarska-Drygalska A,Malinowski KP,Papuga-Szela E,Natorska J,Undas A

更新日期：2019-02-01 00:00:00

abstract：:Anticoagulation is often used in superior vena cava syndrome (SVCS) associated with cancer (i.e malignant SVCS), even without thrombosis, but its effect on outcomes has not been reported. We aimed to determine factors and outcomes associated with thrombosis and anticoagulation in malignant SVCS. Patients with malignan...

journal_title：Journal of thrombosis and thrombolysis

authors： Ratzon R,Tamir S,Friehmann T,Livneh N,Dudnik E,Rozental A,Hamburger-Avnery O,Pereg D,Derazne E,Brenner B,Raanani P,Ten Cate H,Spectre G,Leader A

更新日期：2019-01-01 00:00:00

abstract：:Pump thrombosis remains a serious complication of implantable ventricular assist device therapy and is associated with increased risk of morbidity and mortality. Optimal management strategies remain controversial and are guided largely by limited literature and expert opinion. Medical management of pump thrombosis, in...

journal_title：Journal of thrombosis and thrombolysis

authors： Weeks P,Sieg A,Rajapreyar I,Nathan S,Jumean M,Patel M,Radovancevic R,Kar B,Gregoric I

更新日期：2018-11-01 00:00:00

abstract：:Dual antiplatelet therapy with aspirin and clopidogrel are recommended as adjuncts to fibrinolytic-treated patients with ST-elevation myocardial infarction (STEMI). However, the role of switching to ticagrelor within 24 h of fibrinolytics compared with clopidogrel continuation in this setting is uncertain. Hence, we c...

journal_title：Journal of thrombosis and thrombolysis

authors： Kheiri B,Osman M,Abdalla A,Haykal T,Barbarawi M,Zayed Y,Hicks M,Ahmed S,Bachuwa G,Hassan M,Bhatt DL

更新日期：2018-10-01 00:00:00

abstract：:Patients with acute leukemia frequently develop catheter-related thrombosis (CRT) despite concurrent thrombocytopenia. The incidence, treatment and outcomes of this complication are poorly documented. We undertook this study to determine the incidence of CRT in patients with acute leukemia and assess the safety and ef...

journal_title：Journal of thrombosis and thrombolysis

authors： Htun KT,Ma MJY,Lee AYY

更新日期：2018-10-01 00:00:00

abstract：:Among atrial fibrillation (AF) patients undergoing percutaneous coronary intervention (PCI), rivaroxaban with background antiplatelet therapy significantly reduced the first occurrence of bleeding compared to triple therapy with warfarin. This study hypothesized that total bleeding events, including those beyond the f...

journal_title：Journal of thrombosis and thrombolysis

authors： Chi G,Yee MK,Kalayci A,Kerneis M,AlKhalfan F,Mehran R,Bode C,Halperin JL,Verheugt FWA,Wildgoose P,van Eickels M,Lip GYH,Cohen M,Peterson ED,Fox KAA,Gibson CM

更新日期：2018-10-01 00:00:00

abstract：:To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessa...

journal_title：Journal of thrombosis and thrombolysis

authors： Witberg G,Bathish J,Bental T,Leshem-Lev D,Assali A,Kornowski R,Lev E

更新日期：2018-10-01 00:00:00

abstract：:Continuous flow left ventricular assist devices (CF-LVAD) require therapeutic anticoagulation which is often interrupted for procedures or bleeding. Prior to the availability of four factor prothrombin complex concentrate (4F-PCC) in the United States, warfarin was held and its effects reversed by vitamin K or fresh f...

journal_title：Journal of thrombosis and thrombolysis

authors： Rimsans J,Levesque A,Lyons E,Sylvester K,Givertz MM,Mehra MR,Stewart GC,Connors JM

更新日期：2018-08-01 00:00:00

abstract：:Management of intermediate and high risk acute pulmonary embolism (PE) is challenging. The role of multidisciplinary teams for the care of these patients is emerging. Herein, we report our experience with a pulmonary embolism response team (PERT). We conducted a retrospective chart review on all patients admitted to t...

journal_title：Journal of thrombosis and thrombolysis

authors： Mahar JH,Haddadin I,Sadana D,Gadre A,Evans N,Hornacek D,Mahlay NF,Gomes M,Joseph D,Serhal M,Tong MZ,Bauer SR,Militello M,Silver B,Shishehbor M,Bartholomew JR,Heresi GA

更新日期：2018-08-01 00:00:00

abstract：:Kuperman et al. found that patients with anemia had a higher risk of major bleeding (RR 2.84; 95% CI 2.52-3.39) in RIETE database. Anemia appeared to be an independent predictive factor for major bleeding [hazard ratio (HR) 1.95; 95% CI 1.72-2.20] in this registry. Unfortunately, selection bias due to enrolled patient...

journal_title：Journal of thrombosis and thrombolysis

authors： Gaboreau Y,Zenatti N,Vermorel C,Imbert P,Bosson JL,Pernod G

更新日期：2018-07-01 00:00:00

abstract：:The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to...

journal_title：Journal of thrombosis and thrombolysis

authors： Gorog DA

更新日期：2018-05-01 00:00:00

abstract：:Making a definitive diagnosis of heparin-induced thrombocytopenia (HIT) can be problematic. A prompt platelet rise following treatment has been proposed as a "post-test" criterion for diagnosis. However, the platelet response following discontinuation of heparin and initiation of a recommended alternative anticoagulan...

journal_title：Journal of thrombosis and thrombolysis

authors： Pon TK,Mahajan A,Rosenberg A,Amin A,Shah D,Jenkins I,Gupta V,Hofmann H,Bejjani A,White R

更新日期：2018-05-01 00:00:00

abstract：:Direct oral anticoagulants are associated with rates of major bleeding which are not negligible, albeit lower than those associated with vitamin K antagonists. No specific reversal agent for factor Xa (FXa) direct inhibitors is currently available for clinical use. A modified activated human FXa decoy protein, andexan...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Cosmi B

更新日期：2018-04-01 00:00:00

abstract：:Apixaban is effective and safe for preventing stroke, and its usage has increased exponentially in recent years. However, data concerning the therapeutic range of apixaban is limited. This study determined the trough and peak levels of apixaban-specific anti-factor Xa activity (AFXaA) in acute ischemic stroke patients...

journal_title：Journal of thrombosis and thrombolysis

authors： Shin H,Cho MC,Kim RB,Kim CH,Choi NC,Kim SK,Koh EH

更新日期：2018-02-01 00:00:00